Types of Grafts

Autograft

  • Tissue that is taken from one part of the body and used on a different part of the body in the same individual.
  • Advantage
    • Tissue will be accepted by the body because it is from itself and will┬ánot elicit and immune response. The tissue will not be viewed as a foreign object and attacked.
  • Disadvantage
    • The donor site will be painful, may become infected and will scar

Allograft

  • A tissue graft from a human donor that is not the recipient
  • Advantage
    • Prevents the need of a second surgery to harvest the donor tissue
  • Disadvantage
    • Can stimulate an immune response rejecting the graft; increase risk of disease transfer

Apligraft

  • Keratinocytes and fibroblasts derived from neonatal human foreskin

Dermagraft

  • Cryopreserved human fibroblast within a mesh scaffold

Oasis

  • Porcine derived extracellular matrix

Integra

  • Bovine derived collagen and glycosaminoglycan in a silicone matrix

Epifix

  • Human amniotic membrane derived cells

Cadaveric graft

  • A type of graft where tissue is transferred from a deceased individual to living recipient. The tissue is treated to prevent the transmission of diseases and prevent rejection of the transplant

Embryonic graft

  • This is a newer development of allografts where embryonic stem cells are used to grow skin that can be transplanted to a recipient. Embryonic skin heals without scarring, however it is underdeveloped and lack the same components as adults skin. Further research is being conducted on the use of embryonic grafts. The next generation of allografts are stem cell derived.