A diabetic foot ulcer is an open sore or wound that occurs in approximately 15% of patients with diabetes. These wounds are commonly located on the bottom of the foot. They can occur as a result of various factors, including mechanical changes due to the bony architecture of the foot, peripheral neuropathy, and peripheral arterial disease. These risks factors occur with higher frequency and intensity in the diabetic population. Neuropathy causes loss of protective sensation and loss of coordination of the musculature in the foot and leg. This can lead to increased mechanical stress during ambulation, leading to the development of a wound.